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PUBLICATIONS

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  • Tsai CL, Chang JW, Cheng KY, Lan YJ, Hsu YC, Lin QD, Chen TY, Shih O, Lin CH, Chiang PH, Simenas M, Kalendra V, Chiang YW*, Chen CH*, Jeng US*, Wang SK.* Comprehensive characterization of polyproline tri-helix macrocyclic nanoscaffolds for predictive ligand positioning. Nanoscale Adv. 2024, 6, 947-959. [PubMed] doi: 10.1039/d3na00945a. 

  • Li MC, Liu YJ, Hsu KC, Lin TH, Lin CW, Horng JC, Wang SK.* Design and synthesis of fluorinated peptides for analysis of fluorous effects on the interconversion of polyproline helices. Bioorg Chem. 2022, 119, 105491. [PubMed] doi: 10.1016/j.bioorg.2021.105491. 

  • Lee WH, Chen X, Liu IJ, Lee JH, Hu CM, Wu HC, Wang SK, Lee WH,* Ma C.* Structural basis of interleukin-17B receptor in complex with a neutralizing antibody for guiding humanization and affinity maturation. Cell Rep. 2022, 4, 1111555. [PubMed] doi: 10.1016/j.celrep.2022.111555. 

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  • Tsai CL, Wu SY, Hsu HK, Huang SB, Lin CH, Chan YT,* Wang SK.* Preparation and conformational analysis of polyproline tri-helix macrocycle nanoscaffolds of varied sizes. Nanoscale. 2021, 13, 4592-4601. [PubMed] doi: 10.1039/d0nr08184a. 

  • Pawar S, Hsu L, Narendar Reddy T, Ravinder M, Ren CT, Lin YW, Cheng YY, Lin TW, Hsu TL, Wang SK, Wong CH,* Wu CY.* Synthesis of Asymmetric N-Glycans as Common Core Substrates for Structural Diversification through Selective Enzymatic Glycosylation. ACS Chem Biol. 2020, 15, 2382-2394. [PubMed]  doi: 10.1021/acschembio.0c00359. 

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  • Wen HC, Lin CH, Huang JS, Tsai CL, Chen TF, Wang SK.* Selective targeting of DC-SIGN by controlling the oligomannose pattern on a polyproline tetra-helix macrocycle scaffold. Chem Commun. 2019, 55, 9124-9127. [PubMed] doi: 10.1039/c9cc03124c. 

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  • Lin CH, Wen HC, Chiang CC, Huang JS, Chen Y, Wang SK.* Tri-Helix Macrocycles as Nanosized Scaffolds to Control Ligand Patterns for Selective Protein Oligomer Interactions. Small 2019, 15, e1900561. [Pubmed] doi: 10.1002/smll.201900561.

  • Tseng WH, Li MC, Horng JC, Wang SK.* Strategy and Effects of Polyproline Peptide Stapling by Copper(I)-Catalyzed Alkyne-Azide Cycloaddition Reaction. ChemBioChem. 2019, 20, 153-158. [Pubmed] doi: 10.1002/cbic.201800575.

  • Huang KW, Lai YT, Chern GJ, Huang SF, Tsai CL, Sung YC, Chiang CC, Hwang PB, Ho TL, Huang RL, Shiue TY, Chen Y,* Wang SK.* Derivative-Modified Nanoparticles for Efficient siRNA Delivery to Hepatocellular Carcinoma. Biomacromolecules. 2018, 19, 2330-2339. [Pubmed] doi: 10.1021/acs.biomac.8b00358.

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  • Huang SF, Lin CH, Lai YT, Tsai CL, Cheng TR, Wang SK.* Development of Pseudomonas aeruginosa Lectin LecA Inhibitor by using Bivalent Galactosides Supported on Polyproline Peptide Scaffolds. Chem Asian J. 2018, 13, 686-700. [Pubmed] doi: 10.1002/asia.201701724.

  • Liu CH, Chern GJ, Hsu FF, Huang KW, Sung YC, Huang HC, Qiu JT, Wang SK, Lin CC, Wu CH, Wu HC, Liu JY, Chen Y.* A multifunctional nanocarrier for efficient TRAIL-based gene therapy against hepatocellular carcinoma with desmoplasia in mice. Hepatology. 2018, 67, 899-913. [Pubmed] doi: 10.1002/hep.29513.

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  • Lin TH, Lin CH, Liu YJ, Huang CY, Lin YC, Wang SK.* Controlling Ligand Spacing on Surface: Polyproline-Based Fluorous Microarray as a Tool in Spatial Specificity Analysis and Inhibitor Development for Carbohydrate-Protein Interactions. ACS Appl Mater Interfaces. 2017, 9, 41691-41699. [Pubmed] doi: 10.1021/acsami.7b13200.

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  • Wang SK,* Cheng CM.* Glycan-based diagnostic devices: current progress, challenges and perspectives. Chem Commun. 2015, 51, 16750-62. [Pubmed] doi: 10.1039/c5cc06876b.

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  • Doores KJ, Huber M, Le KM, Wang SK, Doyle-Cooper C, Cooper A, Pantophlet R, Wong CH, Nemazee D, Burton DR.* 2G12-expressing B cell lines may aid in HIV carbohydrate vaccine design strategies. J Virol. 2013, 87, 2234-2241. [Pubmed] doi: 10.1128/JVI.02820-12.

  • Al-Shareffi E, Chaubard JL, Leonhard-Melief C, Wang SK, Wong CH, Haltiwanger RS.* 6-alkynyl fucose is a bioorthogonal analog for O-fucosylation of epidermal growth factor-like repeats and thrombospondin type-1 repeats by protein O-fucosyltransferases 1 and 2. Glycobiology. 2013, 23, 188-198. [Pubmed] doi: 10.1093/glycob/cws140.

  • Pejchal R,† Doores KJ,† Walker LM,† Khayat R,† Huang PS,† Wang SK, Stanfield RL, Julien JP, Ramos A, Crispin M, Depetris R, Katpally U, Marozsan A, Cupo A, Maloveste S, Liu Y, McBride R, Ito Y, Sanders RW, Ogohara C, Paulson JC, Feizi T, Scanlan CN, Wong CH, Moore JP, Olson WC, Ward AB, Poignard P, Schief WR, Burton DR,* Wilson IA.* A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield. Science. 2011, 334, 1097-1103. [Pubmed] doi: 10.1126/science.1213256.

  • Walker LM,† Huber M,† Doores KJ,† Falkowska E, Pejchal R, Julien JP, Wang SK, Ramos A, Chan-Hui PY, Moyle M, Mitcham JL, Hammond PW, Olsen OA, Phung P, Fling S, Wong CH, Phogat S, Wrin T, Simek MD; Protocol G Principal Investigators, Koff WC, Wilson IA, Burton DR,* Poignard P.* Broad neutralization coverage of HIV by multiple highly potent antibodies. Nature. 2011, 477, 466-470. [Pubmed] doi: 10.1038/nature10373.

  • Liang CH,† Wang SK,† Lin CW, Wang CC, Wong CH,* Wu CY.* Effects of neighboring glycans on antibody-carbohydrate interaction. Angew Chem Int Ed. 2011, 50, 1608-1612. [Pubmed] doi: 10.1002/anie.201003482.

  • Astronomo RD, Kaltgrad E, Udit AK, Wang SK, Doores KJ, Huang CY, Pantophlet R, Paulson JC, Wong CH, Finn MG, Burton DR.* Defining criteria for oligomannose immunogens for HIV using icosahedral virus capsid scaffolds. Chem Biol. 2010, 17, 357-370. [Pubmed] doi: 10.1016/j.chembiol.2010.03.012.

  • Wang SK, Liang PH, Astronomo RD, Hsu TL, Hsieh SL, Burton DR, Wong CH.* Targeting the carbohydrates on HIV-1: Interaction of oligomannose dendrons with human monoclonal antibody 2G12 and DC-SIGN. Proc Natl Acad Sci USA. 2008, 105, 3690-3695. [Pubmed] doi: 10.1073/pnas.0712326105.

  • Liang PH, Wang SK, Wong CH. Quantitative analysis of carbohydrate-protein interactions using glycan microarrays: determination of surface and solution dissociation constants. J Am Chem Soc. 2007, 129, 11177-11184. [Pubmed]

  • Hsu TL, Hanson SR, Kishikawa K, Wang SK, Sawa M, Wong CH.* Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells. Proc Natl Acad Sci USA. 2007, 104, 2614-2619. [Pubmed]

  • Sanna MG,† Wang SK,† Gonzalez-Cabrera PJ, Don A, Marsolais D, Matheu MP, Wei SH, Parker I, Jo E, Cheng WC, Cahalan MD, Wong CH,* Rosen H.* Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat Chem Biol. 2006, 2, 434-441. [Pubmed]

  • Wei SH, Rosen H,* Matheu MP, Sanna MG, Wang SK, Jo E, Wong CH, Parker I, Cahalan MD.* Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nat Immunol. 2005, 6, 1228-1235. [Pubmed]

  • Wu CY, Brik A, Wang SK, Chen YH, Wong CH.* Tetrabutylammonium fluoride-mediated rapid alkylation reaction in microtiter plates for the discovery of enzyme inhibitors in situ. ChemBioChem. 2005, 6, 2176-2180. [Pubmed]

  • Liang FS, Wang SK, Nakatani T, Wong CH.* Targeting RNAs with tobramycin analogues. Angew Chem Int Ed. 2004, 43, 6496-6500. [Pubmed]

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  • ​Pratap RP, Chu CY, Hwang, DR, Wang SK, Uang BJ.* Recent advances in the oxovanadium mediated biaryl coupling and modified Mannich-type reactions. Coordin Chem Rev. 2003, 237, 257-269.

  • Chu CY, Hwang DR, Wang SK, Uang BJ.* Chiral oxovanadium complex catalyzed enantioselective oxidative coupling of 2-naphthols. Chem Commun 2001, 980-981.

  • Hwang DR, Chu CY, Wang SK, Uang BJ.* Aerobic oxidation of hydroquinones to quinones catalyzed by VO(acac)2. Synlett 1999, 77-78.​
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